Clinical Applications of Personalized Medicine

PHA5933 – 2 Credits

Personalized medicine involves the use an individual’s genetic profile to guide decisions made in regard to the prevention, diagnosis, and treatment of disease. This course will focus on how pharmacogenomic and genomic medicine data can be used in patient care. Students will be given the opportunity to have their personal DNA genotyped on a custom chip, and utilize this information for the class assignments. Alternatively students may work with a de-identified genotype dataset. This course will use a combination of interprofessional lectures, and case-based discussions of clinical pharmacogenetic guidelines and primary literature. The goal of this course is to provide health professional students with the knowledge and skills to use a personalized medicine approach in their future clinical practice in an interprofessional learning environment.

Course Objectives

  • Explain risks involved with pharmacogenetic testing.
  • Interpret and apply evidence for pharmacogenomics and genomic medicine from the medical literature to patient care.
  • Apply personal or de-identified genetic information to clinical decision-making for representative cases using the following pharmacogenomic drug-gene pairs:
    1. CYP2D6 and codeine
    2. Clopidogrel & CYP2C19
    3. SLCO1B1 and simvastatin
    4. CYP2C9, VKORC1 and warfarin
    5. TPMT and thiopurines
    6. IL28B (IFNL3) and PEG-IFN
  • Apply theoretical genetic information to clinical decision-making and disease risk prediction for the following types of diseases:
    1. Complex Diseases: Cardiovascular Disease Risk
    2. Somatic Genomics: Genomic Medicine in Breast Cancer
  • Demonstrate best practices for returning genetic and pharmacogenetic test results to a patient, including legal and ethical concerns and communication strategies.
  • Demonstrate the contributions and roles of other health care professionals in the clinical application of genomic information to patient care.
  • Summarize the challenges and opportunities in integrating genomic medicine and pharmacogenomics data into the clinical process of patient care.


University of Florida students will be charged the standard graduate tuition rate.  Non-UF students will be charged $1150 in tuition plus fees.


Kristen Weitzel

Kristin Weitzel, PharmD, CDE, FAPhA

Associate Director, UF Health Personalized Medicine Program

Dr. Weitzel received her Pharm.D. from the University of Florida College of Pharmacy.  After graduation, she completed a Community Pharmacy Residency at the Virginia Commonwealth University, Medical College of Virginia School of Pharmacy.   Following her postgraduate training, Dr. Weitzel accepted an appointment as Clinical Assistant Professor at Mercer University School of Pharmacy in Georgia while also working as a Clinical Pharmacist at the Eckerd Patient Care Centers.  In July of 2000, Dr. Weitzel began her affiliation at the University of Florida serving as a Clinical Assistant Professor in Gainesville and later as Adjunct Clinical Associate Professor while maintaining a practice as Outpatient Pharmacy Manager for the St. Vincent’s Health System in Orange Park, Florida.  Dr. Weitzel has also served as Assistant Editor and later as Director of Editorial Projects at the Therapeutic Research Center.  She became Director of Experiential Education in 2011 and began her current appointment as Associate Director of the Personalized Program in July 2013.

Dr. Weitzel’s research interests include technology implementation in community pharmacy practice and preceptor training programs and personalized medicine.

Chris Baylis

Caitrin McDonough, PhD

Research Assistant Professor, Pharmacotherapy and Translational Research

Dr. McDonough received a B.S. in Biochemistry (with a minor in chemistry) from the University of Iowa and then earned a Ph.D in Molecular Medicine and Translational Science from Wake Forest University School of Medicine. Dr. McDonough’s dissertation work focused on the Genetics of Type 2 Diabetic End-Stage Renal Disease in African Americans.  After completing graduate studies, she joined the Department of Pharmacotherapy and Translational Research as a Post-Doctoral Associate in Cardiovascular Pharmacogenomics under the direction of Dr. Julie Johnson.  Dr. McDonough is an investigator in the Center for Pharmacogenomics and plays a central role in the development of genetics education programming for the UF&Shands Personalized Medicine Program.

She also teaches Genetic Medicine concepts to pharmacy students in the Personalized Medicine course.