Content Tagged literature review Subscribe to RSS Feed

Warfarin: Inclusion of genotypes important for African Americans leads to better dose prediction

Published: Dec 15th, 2014

Warfarin is used widely to prevent thromboembolic events. Numerous studies have demonstrated that CYP2C9 and VKORC1 genotypes influence warfarin dosage requirements. However, the Clarification of Optimal Anticoagulation through Genetics (COAG) […]

DPYD and 5-fluorouracil toxicity: Results of largest study to date support association

Published: Dec 1st, 2014

Use of the antimetabolite 5-fluorouracil (5–FU) is associated with variability in both efficacy and toxicity. Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting catabolic enzyme for 5–FU and eliminates approximately 85% of […]

Clopidogrel in CYP2C19 poor metabolizers: Four-fold dose increase may be needed

Published: Aug 31st, 2014

Clopidogrel is an antiplatelet agent that is bioactivated through a two-step process involving the polymorphic CYP2C19 enzyme. CYP2C19 genotype can be used to predict clopidogrel response, particularly in patients undergoing […]

CYP2D6 drug interactions and response to hydrocodone, ondansetron

Published: Aug 24th, 2014

Joseph Ladd, University of Florida College of Pharmacy 2015 PharmD Candidate The CYP2D6 enzyme is involved in the metabolism of roughly 25% of all medications, including codeine, hydrocodone, oxycodone, and […]

New position statements give guidance on personalized medicine in cardiology, oncology

Published: Aug 15th, 2014

Two recently published position papers from the European Society of Cardiology (ESC) and the European Society for Medical Oncology (ESMO) summarized the current state of personalized medicine, future challenges, and […]

Rheumatology

Published: Aug 12th, 2014

Following is a digest of pharmacogenomics journal articles pertaining to rheumatology. The SNP•its editorial team selects articles for inclusion based on clinical relevance and scientific validity. Journal articles that are most […]

Respiratory

Published: Aug 12th, 2014

Following is a digest of pharmacogenomics journal articles pertaining to respiratory conditions.  The SNP•its editorial team selects articles for inclusion based on clinical relevance and scientific validity. Journal articles that are […]

Psychiatry

Published: Aug 12th, 2014

Following is a digest of pharmacogenomics journal articles pertaining to psychiatry. The SNP•its editorial team selects articles for inclusion based on clinical relevance and scientific validity. Journal articles that are most […]

Pain Management

Published: Aug 12th, 2014

Following is a digest of pharmacogenomics journal articles pertaining to pain. The SNP•its editorial team selects articles for inclusion based on clinical relevance and scientific validity. Journal articles that are most […]

Neurology

Published: Aug 12th, 2014

Following is a digest of pharmacogenomics journal articles pertaining to neurology. The SNP•its editorial team selects articles for inclusion based on clinical relevance and scientific validity. Journal articles that are most […]