Clinical Applications of Personalized Medicine
Personalized medicine involves the use an individual’s genetic profile to guide decisions made in regard to the prevention, diagnosis, and treatment of disease. This course will focus on how pharmacogenomic and genomic medicine data can be used in patient care. Students will be given the opportunity to have their personal DNA genotyped on a custom chip, and utilize this information for the class assignments. Alternatively students may work with a de-identified genotype dataset. This course will use a combination of interprofessional lectures, and case-based discussions of clinical pharmacogenetic guidelines and primary literature. The goal of this course is to provide health professional students with the knowledge and skills to use a personalized medicine approach in their future clinical practice in an interprofessional learning environment.
- Explain risks involved with pharmacogenetic testing.
- Interpret and apply evidence for pharmacogenomics and genomic medicine from the medical literature to patient care.
- Apply personal or de-identified genetic information to clinical decision-making for representative cases using the following pharmacogenomic drug-gene pairs:
- CYP2D6 and codeine
- Clopidogrel & CYP2C19
- SLCO1B1 and simvastatin
- CYP2C9, VKORC1 and warfarin
- TPMT and thiopurines
- IL28B (IFNL3) and PEG-IFN
- Apply theoretical genetic information to clinical decision-making and disease risk prediction for the following types of diseases:
- Complex Diseases: Cardiovascular Disease Risk
- Somatic Genomics: Genomic Medicine in Breast Cancer
- Demonstrate best practices for returning genetic and pharmacogenetic test results to a patient, including legal and ethical concerns and communication strategies.
- Demonstrate the contributions and roles of other health care professionals in the clinical application of genomic information to patient care.
- Summarize the challenges and opportunities in integrating genomic medicine and pharmacogenomics data into the clinical process of patient care.
University of Florida students will be charged the standard graduate tuition rate. Non-UF students will be charged $1150 in tuition plus fees.
Kristin Weitzel, PharmD, CDE, FAPhA
Caitrin McDonough, PhD